Ex vivo model of congenital cytomegalovirus infection and new combination therapies.
Identifieur interne : 002E22 ( Main/Exploration ); précédent : 002E21; suivant : 002E23Ex vivo model of congenital cytomegalovirus infection and new combination therapies.
Auteurs : L. Morère [France] ; D. Andouard [France] ; F. Labrousse [France] ; F. Saade [France] ; C-A Calliste [France] ; S. Cotin [France] ; Y. Aubard [France] ; W D Rawlinson [Australie] ; F. Esclaire [France] ; S. Hantz [France] ; M-C Ploy [France] ; S. Alain [France]Source :
- Placenta [ 1532-3102 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Artémisinines (pharmacologie), Artémisinines (usage thérapeutique), Benzimidazoles (pharmacologie), Benzimidazoles (usage thérapeutique), Complications de la grossesse et maladies infectieuses (traitement médicamenteux), Complications de la grossesse et maladies infectieuses (virologie), Femelle, Flavanones (pharmacologie), Flavanones (usage thérapeutique), Grossesse, Humains, Infections à cytomégalovirus (), Infections à cytomégalovirus (traitement médicamenteux), Ribonucléosides (pharmacologie), Ribonucléosides (usage thérapeutique), Trophoblastes (), Trophoblastes (virologie).
- MESH :
- pharmacologie : Antiviraux, Artémisinines, Benzimidazoles, Flavanones, Ribonucléosides.
- traitement médicamenteux : Complications de la grossesse et maladies infectieuses, Infections à cytomégalovirus.
- usage thérapeutique : Antiviraux, Artémisinines, Benzimidazoles, Flavanones, Ribonucléosides.
- virologie : Complications de la grossesse et maladies infectieuses, Trophoblastes.
- Adulte, Femelle, Grossesse, Humains, Infections à cytomégalovirus, Trophoblastes.
English descriptors
- KwdEn :
- Adult, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Artemisinins (pharmacology), Artemisinins (therapeutic use), Benzimidazoles (pharmacology), Benzimidazoles (therapeutic use), Cytomegalovirus Infections (congenital), Cytomegalovirus Infections (drug therapy), Female, Flavanones (pharmacology), Flavanones (therapeutic use), Humans, Pregnancy, Pregnancy Complications, Infectious (drug therapy), Pregnancy Complications, Infectious (virology), Ribonucleosides (pharmacology), Ribonucleosides (therapeutic use), Trophoblasts (drug effects), Trophoblasts (virology).
- MESH :
- chemical , pharmacology : Antiviral Agents, Artemisinins, Benzimidazoles, Flavanones, Ribonucleosides.
- chemical , therapeutic use : Antiviral Agents, Artemisinins, Benzimidazoles, Flavanones, Ribonucleosides.
- congenital : Cytomegalovirus Infections.
- drug effects : Trophoblasts.
- drug therapy : Cytomegalovirus Infections, Pregnancy Complications, Infectious.
- virology : Pregnancy Complications, Infectious, Trophoblasts.
- Adult, Female, Humans, Pregnancy.
Abstract
Congenital human cytomegalovirus (HCMV) infection is a major public health problem due to severe sequelae in the fetus and newborns. Currently, due to their toxicity anti-CMV treatments cannot be administered to pregnant women. We thus developed an ex vivo model of 1(st) trimester placental CMV infection to observe the route of infection across the placenta and to test the efficacy of various new drugs targeting different stages of viral cycle.
DOI: 10.1016/j.placenta.2014.11.003
PubMed: 25479789
Affiliations:
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Le document en format XML
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Aubard</name><affiliation wicri:level="3"><nlm:affiliation>CHU de Limoges, Gynecology-Obstetrics Department, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU de Limoges, Gynecology-Obstetrics Department, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Rawlinson, W D" sort="Rawlinson, W D" uniqKey="Rawlinson W" first="W D" last="Rawlinson">W D Rawlinson</name><affiliation wicri:level="1"><nlm:affiliation>Virology Division, SEALS Microbiology Prince of Wales Hospital and SOMS, BABS UNSW, Randwick, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Virology Division, SEALS Microbiology Prince of Wales Hospital and SOMS, BABS UNSW, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation></author><author><name sortKey="Esclaire, F" sort="Esclaire, F" uniqKey="Esclaire F" first="F" last="Esclaire">F. 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Alain</name><affiliation wicri:level="3"><nlm:affiliation>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges, France. 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Morère</name><affiliation wicri:level="3"><nlm:affiliation>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Andouard, D" sort="Andouard, D" uniqKey="Andouard D" first="D" last="Andouard">D. Andouard</name><affiliation wicri:level="3"><nlm:affiliation>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Labrousse, F" sort="Labrousse, F" uniqKey="Labrousse F" first="F" last="Labrousse">F. Labrousse</name><affiliation wicri:level="3"><nlm:affiliation>CHU de Limoges, Anatomopathology Department, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU de Limoges, Anatomopathology Department, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Saade, F" sort="Saade, F" uniqKey="Saade F" first="F" last="Saade">F. Saade</name><affiliation wicri:level="3"><nlm:affiliation>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Calliste, C A" sort="Calliste, C A" uniqKey="Calliste C" first="C-A" last="Calliste">C-A Calliste</name><affiliation wicri:level="3"><nlm:affiliation>Faculty of Pharmacy, University of Limoges, LCSN-EA1069, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculty of Pharmacy, University of Limoges, LCSN-EA1069, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Cotin, S" sort="Cotin, S" uniqKey="Cotin S" first="S" last="Cotin">S. Cotin</name><affiliation wicri:level="3"><nlm:affiliation>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Aubard, Y" sort="Aubard, Y" uniqKey="Aubard Y" first="Y" last="Aubard">Y. Aubard</name><affiliation wicri:level="3"><nlm:affiliation>CHU de Limoges, Gynecology-Obstetrics Department, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU de Limoges, Gynecology-Obstetrics Department, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Rawlinson, W D" sort="Rawlinson, W D" uniqKey="Rawlinson W" first="W D" last="Rawlinson">W D Rawlinson</name><affiliation wicri:level="1"><nlm:affiliation>Virology Division, SEALS Microbiology Prince of Wales Hospital and SOMS, BABS UNSW, Randwick, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Virology Division, SEALS Microbiology Prince of Wales Hospital and SOMS, BABS UNSW, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation></author><author><name sortKey="Esclaire, F" sort="Esclaire, F" uniqKey="Esclaire F" first="F" last="Esclaire">F. Esclaire</name><affiliation wicri:level="3"><nlm:affiliation>CHU de Limoges, Mother and Child Hospital, Histopathology Department, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU de Limoges, Mother and Child Hospital, Histopathology Department, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Hantz, S" sort="Hantz, S" uniqKey="Hantz S" first="S" last="Hantz">S. Hantz</name><affiliation wicri:level="3"><nlm:affiliation>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Ploy, M C" sort="Ploy, M C" uniqKey="Ploy M" first="M-C" last="Ploy">M-C Ploy</name><affiliation wicri:level="3"><nlm:affiliation>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author><author><name sortKey="Alain, S" sort="Alain, S" uniqKey="Alain S" first="S" last="Alain">S. Alain</name><affiliation wicri:level="3"><nlm:affiliation>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges, France. Electronic address: sophie.alain@unilim.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Limoges, Inserm U1092, Limoges, France; INSERM, UMR 1092, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Limoges, France; French National Reference Center for Cytomegaloviruses, Limoges</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Limousin</region><settlement type="city">Limoges</settlement></placeName></affiliation></author></analytic><series><title level="j">Placenta</title><idno type="eISSN">1532-3102</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Artemisinins (pharmacology)</term><term>Artemisinins (therapeutic use)</term><term>Benzimidazoles (pharmacology)</term><term>Benzimidazoles (therapeutic use)</term><term>Cytomegalovirus Infections (congenital)</term><term>Cytomegalovirus Infections (drug therapy)</term><term>Female</term><term>Flavanones (pharmacology)</term><term>Flavanones (therapeutic use)</term><term>Humans</term><term>Pregnancy</term><term>Pregnancy Complications, Infectious (drug therapy)</term><term>Pregnancy Complications, Infectious (virology)</term><term>Ribonucleosides (pharmacology)</term><term>Ribonucleosides (therapeutic use)</term><term>Trophoblasts (drug effects)</term><term>Trophoblasts (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Artémisinines (pharmacologie)</term><term>Artémisinines (usage thérapeutique)</term><term>Benzimidazoles (pharmacologie)</term><term>Benzimidazoles (usage thérapeutique)</term><term>Complications de la grossesse et maladies infectieuses (traitement médicamenteux)</term><term>Complications de la grossesse et maladies infectieuses (virologie)</term><term>Femelle</term><term>Flavanones (pharmacologie)</term><term>Flavanones (usage thérapeutique)</term><term>Grossesse</term><term>Humains</term><term>Infections à cytomégalovirus ()</term><term>Infections à cytomégalovirus (traitement médicamenteux)</term><term>Ribonucléosides (pharmacologie)</term><term>Ribonucléosides (usage thérapeutique)</term><term>Trophoblastes ()</term><term>Trophoblastes (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Artemisinins</term><term>Benzimidazoles</term><term>Flavanones</term><term>Ribonucleosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Artemisinins</term><term>Benzimidazoles</term><term>Flavanones</term><term>Ribonucleosides</term></keywords><keywords scheme="MESH" qualifier="congenital" xml:lang="en"><term>Cytomegalovirus Infections</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Trophoblasts</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cytomegalovirus Infections</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Artémisinines</term><term>Benzimidazoles</term><term>Flavanones</term><term>Ribonucléosides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications de la grossesse et maladies infectieuses</term><term>Infections à cytomégalovirus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Artémisinines</term><term>Benzimidazoles</term><term>Flavanones</term><term>Ribonucléosides</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Complications de la grossesse et maladies infectieuses</term><term>Trophoblastes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pregnancy Complications, Infectious</term><term>Trophoblasts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Pregnancy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Infections à cytomégalovirus</term><term>Trophoblastes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Congenital human cytomegalovirus (HCMV) infection is a major public health problem due to severe sequelae in the fetus and newborns. Currently, due to their toxicity anti-CMV treatments cannot be administered to pregnant women. We thus developed an ex vivo model of 1(st) trimester placental CMV infection to observe the route of infection across the placenta and to test the efficacy of various new drugs targeting different stages of viral cycle.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Limousin</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Limoges</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Morere, L" sort="Morere, L" uniqKey="Morere L" first="L" last="Morère">L. Morère</name></region><name sortKey="Alain, S" sort="Alain, S" uniqKey="Alain S" first="S" last="Alain">S. Alain</name><name sortKey="Andouard, D" sort="Andouard, D" uniqKey="Andouard D" first="D" last="Andouard">D. Andouard</name><name sortKey="Aubard, Y" sort="Aubard, Y" uniqKey="Aubard Y" first="Y" last="Aubard">Y. Aubard</name><name sortKey="Calliste, C A" sort="Calliste, C A" uniqKey="Calliste C" first="C-A" last="Calliste">C-A Calliste</name><name sortKey="Cotin, S" sort="Cotin, S" uniqKey="Cotin S" first="S" last="Cotin">S. Cotin</name><name sortKey="Esclaire, F" sort="Esclaire, F" uniqKey="Esclaire F" first="F" last="Esclaire">F. Esclaire</name><name sortKey="Hantz, S" sort="Hantz, S" uniqKey="Hantz S" first="S" last="Hantz">S. Hantz</name><name sortKey="Labrousse, F" sort="Labrousse, F" uniqKey="Labrousse F" first="F" last="Labrousse">F. Labrousse</name><name sortKey="Ploy, M C" sort="Ploy, M C" uniqKey="Ploy M" first="M-C" last="Ploy">M-C Ploy</name><name sortKey="Saade, F" sort="Saade, F" uniqKey="Saade F" first="F" last="Saade">F. Saade</name></country><country name="Australie"><noRegion><name sortKey="Rawlinson, W D" sort="Rawlinson, W D" uniqKey="Rawlinson W" first="W D" last="Rawlinson">W D Rawlinson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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